Regulation of Cyclooxygenase-2 Expression by the Translational Silencer TIA-1

The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of prostaglandin formation in inflammatory states, and COX-2 overexpression plays a key role in carcinogenesis. To understand the mechanisms regulating COX-2 expression, we examined its posttranscriptional regulation mediated throu...

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Detalles Bibliográficos
Main Authors: Dixon, Dan A., Balch, Glen C., Kedersha, Nancy, Anderson, Paul, Zimmerman, Guy A., Beauchamp, R. Daniel, Prescott, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2003
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194089/
https://ncbi.nlm.nih.gov/pubmed/12885872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030616
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