ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors

p73 has significant homology to p53. However, tumor-associated up-regulation of p73 and genetic data from human tumors and p73-deficient mice exclude a classical Knudson-type tumor suppressor role. We report that the human TP73 gene generates an NH(2) terminally truncated isoform. ΔNp73 derives from...

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Hauptverfasser: Zaika, Alex I., Slade, Neda, Erster, Susan H., Sansome, Christine, Joseph, Troy W., Pearl, Michael, Chalas, Eva, Moll, Ute M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194062/
https://ncbi.nlm.nih.gov/pubmed/12235210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020179
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