Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein–deficient Mice: Evidence for Osteopontin as an Inducible Inhibitor of Vascular Calcification In Vivo

Osteopontin (OPN) is abundantly expressed in human calcified arteries. To examine the role of OPN in vascular calcification, OPN mutant mice were crossed with matrix Gla protein (MGP) mutant mice. Mice deficient in MGP alone (MGP(−/−) OPN(+/+)) showed calcification of their arteries as early as 2 we...

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Main Authors: Speer, Mei Y., McKee, Marc D., Guldberg, Robert E., Liaw, Lucy, Yang, Hsueh-Ying, Tung, Elyse, Karsenty, Gerard, Giachelli, Cecilia M.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2002
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194039/
https://ncbi.nlm.nih.gov/pubmed/12391016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020911
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