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Inactivation of the Osteopontin Gene Enhances Vascular Calcification of Matrix Gla Protein–deficient Mice: Evidence for Osteopontin as an Inducible Inhibitor of Vascular Calcification In Vivo

Osteopontin (OPN) is abundantly expressed in human calcified arteries. To examine the role of OPN in vascular calcification, OPN mutant mice were crossed with matrix Gla protein (MGP) mutant mice. Mice deficient in MGP alone (MGP(−/−) OPN(+/+)) showed calcification of their arteries as early as 2 we...

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書誌詳細
主要な著者: Speer, Mei Y., McKee, Marc D., Guldberg, Robert E., Liaw, Lucy, Yang, Hsueh-Ying, Tung, Elyse, Karsenty, Gerard, Giachelli, Cecilia M.
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194039/
https://ncbi.nlm.nih.gov/pubmed/12391016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020911
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