I-PLA(2) Activation during Apoptosis Promotes the Exposure of Membrane Lysophosphatidylcholine Leading to Binding by Natural Immunoglobulin M Antibodies and Complement Activation

Deficiency of serum immunoglobulin (Ig)M is associated with the development of a lupus-like disease in mice. Recent studies suggest that classical complement components facilitate the clearance of apoptotic cells and that failure to do so predisposes mice to lupus. Since IgM is a potent activator of...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Sun Jun, Gershov, Debra, Ma, Xiaojing, Brot, Nathan, Elkon, Keith B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2002
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194002/
https://ncbi.nlm.nih.gov/pubmed/12208880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020542
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