The Lectin-like Domain of Thrombomodulin Confers Protection from Neutrophil-mediated Tissue Damage by Suppressing Adhesion Molecule Expression via Nuclear Factor κB and Mitogen-activated Protein Kinase Pathways

Thrombomodulin (TM) is a vascular endothelial cell (EC) receptor that is a cofactor for thrombin-mediated activation of the anticoagulant protein C. The extracellular NH(2)-terminal domain of TM has homology to C-type lectins that are involved in immune regulation. Using transgenic mice that lack th...

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Main Authors: Conway, Edward M., Van de Wouwer, Marlies, Pollefeyt, Saskia, Jurk, Kerstin, Van Aken, Hugo, De Vriese, Astrid, Weitz, Jeffrey I., Weiler, Hartmut, Hellings, Peter W., Schaeffer, Paul, Herbert, Jean-Marc, Collen, Désiré, Theilmeier, Gregor
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193995/
https://ncbi.nlm.nih.gov/pubmed/12208873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020077
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