Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure

We explored the physiologic role of endothelial cell apoptosis during development by generating mouse embryos lacking the inhibitor of apoptosis protein (IAP) survivin in endothelium. This was accomplished by intercrossing survivin(lox/lox) mice with mice expressing cre recombinase under the control...

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Detalhes bibliográficos
Main Authors: Zwerts, Femke, Lupu, Florea, De Vriese, Astrid, Pollefeyt, Saskia, Moons, Lieve, Altura, Rachel A., Jiang, Yuying, Maxwell, Patrick H., Hill, Peter, Oh, Hideyasu, Rieker, Claus, Collen, Désiré, Conway, Simon J., Conway, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885533/
https://ncbi.nlm.nih.gov/pubmed/17299096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-028068
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