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Expression of a Targeted λ1 Light Chain Gene Is Developmentally Regulated and Independent of Igκ Rearrangements

Immunoglobulin light chain (IgL) rearrangements occur more frequently at Igκ than at Igλ. Previous results suggested that the unrearranged Igκ locus negatively regulates Igλ transcription and/or rearrangement. Here, we demonstrate that expression of a VJλ1-joint inserted into its physiological posit...

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Bibliografiske detaljer
Main Authors: Oberdoerffer, Philipp, Novobrantseva, Tatiana I., Rajewsky, Klaus
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193966/
https://ncbi.nlm.nih.gov/pubmed/12719477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030402
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