CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

The T cell costimulatory molecule CD28 is important for T cell survival, yet both the signaling pathways downstream of CD28 and the apoptotic pathways they antagonize remain poorly understood. Here we demonstrate that CD4(+) T cells from CD28-deficient mice show increased susceptibility to Fas-media...

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Main Authors: Jones, Russell G., Elford, Alisha R., Parsons, Michael J., Wu, Linda, Krawczyk, Connie M., Yeh, Wen-Chen, Hakem, Razqallah, Rottapel, Robert, Woodgett, James R., Ohashi, Pamela S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193932/
https://ncbi.nlm.nih.gov/pubmed/12163562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020307
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