An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4

The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus inhibiting tumor growth. These multiple activities are apparently mediated by a unique G protein–coupled receptor, termed CXCR3. The c...

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Autors principals: Lasagni, Laura, Francalanci, Michela, Annunziato, Francesco, Lazzeri, Elena, Giannini, Stefano, Cosmi, Lorenzo, Sagrinati, Costanza, Mazzinghi, Benedetta, Orlando, Claudio, Maggi, Enrico, Marra, Fabio, Romagnani, Sergio, Serio, Mario, Romagnani, Paola
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2003
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193908/
https://ncbi.nlm.nih.gov/pubmed/12782716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021897
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