Transgenic Expression of the Activating Natural Killer Receptor Ly49H Confers Resistance to Cytomegalovirus in Genetically Susceptible Mice

Natural resistance to infection with mouse cytomegalovirus (MCMV) is controlled by a dominant locus, Cmv1. Cmv1 is linked to the Ly49 family of natural killer receptors on distal chromosome 6. While some studies localized Cmv1 as distal to the Ly49 gene cluster, genetic and functional analysis ident...

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Main Authors: Lee, Seung-Hwan, Zafer, Ahmed, de Repentigny, Yves, Kothary, Rashmi, Tremblay, Michel L., Gros, Philippe, Duplay, Pascale, Webb, John R., Vidal, Silvia M.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193863/
https://ncbi.nlm.nih.gov/pubmed/12591908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021713
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