Locally Up-regulated Lymphotoxin α, Not Systemic Tumor Necrosis Factor α, Is the Principle Mediator of Murine Cerebral Malaria

Cerebral malaria (CM) causes death in children and nonimmune adults. TNF-α has been thought to play a key role in the development of CM. In contrast, the role of the related cyto-kine lymphotoxin α (LTα) in CM has been overlooked. Here we show that LTα, not TNFα, is the principal mediator of murine...

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Detalhes bibliográficos
Main Authors: Engwerda, Christian R., Mynott, Tracey L., Sawhney, Sanjeet, De Souza, J. Brian, Bickle, Quentin D., Kaye, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193758/
https://ncbi.nlm.nih.gov/pubmed/12021316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020128
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