Rapid Induction of Tumor-specific Type 1 T Helper Cells in Metastatic Melanoma Patients by Vaccination with Mature, Cryopreserved, Peptide-loaded Monocyte-derived Dendritic Cells

There is consensus that an optimized cancer vaccine will have to induce not only CD8(+) cytotoxic but also CD4(+) T helper (Th) cells, particularly interferon (IFN)-γ–producing, type 1 Th cells. The induction of strong, ex vivo detectable type 1 Th cell responses has not been reported to date. We de...

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Autores principales: Schuler-Thurner, Beatrice, Schultz, Erwin S., Berger, Thomas G., Weinlich, Georg, Ebner, Susanne, Woerl, Petra, Bender, Armin, Feuerstein, Bernadette, Fritsch, Peter O., Romani, Nikolaus, Schuler, Gerold
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193752/
https://ncbi.nlm.nih.gov/pubmed/12021308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20012100
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