Absence of γ-Interferon–inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes

Long-lasting tumor immunity requires functional mobilization of CD8(+) and CD4(+) T lymphocytes. CD4(+) T cell activation is enhanced by presentation of shed tumor antigens by professional antigen-presenting cells (APCs), coupled with display of similar antigenic epitopes by major histocompatibility...

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Autores principales: Haque, M. Azizul, Li, Ping, Jackson, Sheila K., Zarour, Hassane M., Hawes, John W., Phan, Uyen T., Maric, Maja, Cresswell, Peter, Blum, Janice S.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193747/
https://ncbi.nlm.nih.gov/pubmed/12021307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011853
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