Sialic Acid Binding Domains of CD22 Are Required For Negative Regulation of B Cell Receptor Signaling

CD22, a negative regulator of B cell antigen receptor signaling, binds glycoconjugates terminating in α2, 6 sialic acid. The physiological ligand(s) for CD22 remain unknown. We asked whether the sialic acid binding domains are necessary for CD22 to function as a negative regulator. We generated two...

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Bibliografiske detaljer
Main Authors: Jin, Lei, McLean, Paul A., Neel, Benjamin G., Wortis, Henry H.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2002
Fag:
Brief Definitive Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193702/
https://ncbi.nlm.nih.gov/pubmed/11994425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011796
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