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Germinal Center B Cells Regulate Their Capability to Present Antigen by Modulation of HLA-DO
Peptide acquisition by MHC class II molecules is catalyzed by HLA-DM (DM). In B cells, HLA-DO (DO) inhibits or modifies the peptide exchange activity of DM. We show here that DO protein levels are modulated during B cell differentiation. Remarkably, germinal center (GC) B cells, which have low level...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193692/ https://ncbi.nlm.nih.gov/pubmed/11956297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20012059 |
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