Targeted Deletion of a High-Affinity GATA-binding Site in the GATA-1 Promoter Leads to Selective Loss of the Eosinophil Lineage In Vivo

Transcription factor GATA-1 reprograms immature myeloid cells to three different hematopoietic lineages-erythroid cells, megakaryocytes, and eosinophils. GATA-1 is essential for maturation of erythroid and megakaryocytic precursors, as revealed by gene targeting in mice. Here we demonstrate that del...

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Bibliographic Details
Main Authors: Yu, Channing, Cantor, Alan B., Yang, Haidi, Browne, Carol, Wells, Richard A., Fujiwara, Yuko, Orkin, Stuart H.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193547/
https://ncbi.nlm.nih.gov/pubmed/12045237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020656
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