A “knockdown” mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1

The hematopoietic-restricted transcription factor GATA-1 is required for both mammalian erythroid cell and megakaryocyte differentiation. To define the mechanisms governing its transcriptional regulation, we replaced upstream sequences including a DNase I hypersensitive (HS) region with a neomycin-r...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	McDevitt, Michael A., Shivdasani, Ramesh A., Fujiwara, Yuko, Yang, Haidi, Orkin, Stuart H.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21235/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192642/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6781
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