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CD8(+) T Cell Tolerance to a Tumor-associated Antigen Is Maintained at the Level of Expansion Rather than Effector Function

CD8(+) T cell tolerance to self-proteins prevents autoimmunity but represents an obstacle to generating T cell responses to tumor-associated antigens. We have made a T cell receptor (TCR) transgenic mouse specific for a tumor antigen and crossed TCR-TG mice to transgenic mice expressing the tumor an...

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Main Authors: Öhlén, Claes, Kalos, Michael, Cheng, Laurence E., Shur, Aaron C., Hong, Doley J., Carson, Bryan D., Kokot, Niels C.T., Lerner, Cara G., Sather, Blythe D., Huseby, Eric S., Greenberg, Philip D.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2002
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193546/
https://ncbi.nlm.nih.gov/pubmed/12045239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011063
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