Reprogramming of the Macrophage Transcriptome in Response to Interferon-γ and Mycobacterium tuberculosis : Signaling Roles of Nitric Oxide Synthase-2 and Phagocyte Oxidase

Macrophage activation determines the outcome of infection by Mycobacterium tuberculosis (Mtb). Interferon-γ (IFN-γ) activates macrophages by driving Janus tyrosine kinase (JAK)/signal transducer and activator of transcription–dependent induction of transcription and PKR-dependent suppression of tran...

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Bibliografiske detaljer
Main Authors: Ehrt, Sabine, Schnappinger, Dirk, Bekiranov, Stefan, Drenkow, Jörg, Shi, Shuangping, Gingeras, Thomas R., Gaasterland, Terry, Schoolnik, Gary, Nathan, Carl
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2001
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193509/
https://ncbi.nlm.nih.gov/pubmed/11602641
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