Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype Cd8(+) T Cells

Inflammation likely has a role in the early genesis of certain malignancies. Interleukin (IL)-15, a proinflammatory cytokine and growth factor, is required for lymphocyte homeostasis. Intriguingly, the expression of IL-15 protein is tightly controlled by multiple posttranscriptional mechanisms. Here...

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Main Authors: Fehniger, Todd A., Suzuki, Kazuhiro, Ponnappan, Anand, VanDeusen, Jeffrey B., Cooper, Megan A., Florea, Sorin M., Freud, Aharon G., Robinson, Michael L., Durbin, Joan, Caligiuri, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2001
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193336/
https://ncbi.nlm.nih.gov/pubmed/11208862
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