Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate multiple autoimmune features. We report here that the ligand of PD-1 (PD-L1) is a member of the B7 gene family. Engageme...

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書誌詳細
主要な著者: Freeman, Gordon J., Long, Andrew J., Iwai, Yoshiko, Bourque, Karen, Chernova, Tatyana, Nishimura, Hiroyuki, Fitz, Lori J., Malenkovich, Nelly, Okazaki, Taku, Byrne, Michael C., Horton, Heidi F., Fouser, Lynette, Carter, Laura, Ling, Vincent, Bowman, Michael R., Carreno, Beatriz M., Collins, Mary, Wood, Clive R., Honjo, Tasuku
フォーマット: Artigo
言語:Inglês
出版事項: The Rockefeller University Press 2000
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193311/
https://ncbi.nlm.nih.gov/pubmed/11015443
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