Blockade of T Lymphocyte Costimulation with Cytotoxic T Lymphocyte–Associated Antigen 4–Immunoglobulin (Ctla4ig) Reverses the Cellular Pathology of Psoriatic Plaques, Including the Activation of Keratinocytes, Dendritic Cells, and Endothelial Cells

Efficient T cell activation is dependent on the intimate contact between antigen-presenting cells (APCs) and T cells. The engagement of the B7 family of molecules on APCs with CD28 and CD152 (cytotoxic T lymphocyte–associated antigen 4 [CTLA-4]) receptors on T cells delivers costimulatory signal(s)...

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Autori principali: Abrams, Judith R., Kelley, Susan L., Hayes, Elizabeth, Kikuchi, Toyoko, Brown, Michael J., Kang, Sewon, Lebwohl, Mark G., Guzzo, Cynthia A., Jegasothy, Brian V., Linsley, Peter S., Krueger, James G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2000
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193278/
https://ncbi.nlm.nih.gov/pubmed/10974034
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