Blockade of Transforming Growth Factor β/Smad Signaling in T Cells by Overexpression of Smad7 Enhances Antigen-Induced Airway Inflammation and Airway Reactivity

Transforming growth factor (TGF)-β has been implicated in immunosuppression. However, it remains obscure whether regulation of T cells by TGF-β contributes to the immunosuppression in vivo. To address this issue, we developed transgenic mice expressing Smad7, an intracellular antagonist of TGF-β/Sma...

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Detalhes bibliográficos
Main Authors: Nakao, Atsuhito, Miike, Satoshi, Hatano, Masahiko, Okumura, Ko, Tokuhisa, Takeshi, Ra, Chisei, Iwamoto, Itsuo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2000
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193250/
https://ncbi.nlm.nih.gov/pubmed/10899902
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