Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis

High systemic levels of osteoprotegerin (OPG) in OPG transgenic mice cause osteopetrosis with normal tooth eruption and bone elongation and inhibit the development and activity of endosteal, but not periosteal, osteoclasts. We demonstrate that both intravenous injection of recombinant OPG protein an...

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Hlavní autoři: Min, Hosung, Morony, Sean, Sarosi, Ildiko, Dunstan, Colin R., Capparelli, Casey, Scully, Sheila, Van, Gwyneth, Kaufman, Steve, Kostenuik, Paul J., Lacey, David L., Boyle, William J., Simonet, W. Scott
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2000
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193236/
https://ncbi.nlm.nih.gov/pubmed/10952716
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