Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis

High systemic levels of osteoprotegerin (OPG) in OPG transgenic mice cause osteopetrosis with normal tooth eruption and bone elongation and inhibit the development and activity of endosteal, but not periosteal, osteoclasts. We demonstrate that both intravenous injection of recombinant OPG protein an...

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Main Authors: Min, Hosung, Morony, Sean, Sarosi, Ildiko, Dunstan, Colin R., Capparelli, Casey, Scully, Sheila, Van, Gwyneth, Kaufman, Steve, Kostenuik, Paul J., Lacey, David L., Boyle, William J., Simonet, W. Scott
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2000
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193236/
https://ncbi.nlm.nih.gov/pubmed/10952716
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