Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

Caspase-9 is critical for cytochrome c (cyto-c)-dependent apoptosis and normal brain development. We determined that this apical protease in the cyto-c pathway for apoptosis resides inside mitochondria in several types of cells, including cardiomyocytes and many neurons. Caspase-9 is released from i...

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Detalhes bibliográficos
Main Authors: Krajewski, Stanislaw, Krajewska, Maryla, Ellerby, Lisa M., Welsh, Kate, Xie, Zhihua, Deveraux, Quinn L., Salvesen, Guy S., Bredesen, Dale E., Rosenthal, Robert E., Fiskum, Gary, Reed, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21932/
https://ncbi.nlm.nih.gov/pubmed/10318956
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