FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction: A New Role for FAS Ligand in Inflammatory Responses

Ligation of the Fas (CD95) receptor leads to an apoptotic death signal in T cells, B cells, and macrophages. However, human CD34(+)–derived dendritic cells (DCs) and mouse DCs, regardless of their maturation state, are not susceptible to Fas-induced cell death. This resistance correlates with the co...

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Bibliographic Details
Main Authors: Rescigno, Maria, Piguet, Vincent, Valzasina, Barbara, Lens, Suzanne, Zubler, Rudolf, French, Lars, Kindler, Vincent, Tschopp, Jurg, Ricciardi-Castagnoli, Paola
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193091/
https://ncbi.nlm.nih.gov/pubmed/11104808
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