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Recognition of the Major Histocompatibility Complex Restriction Element Modulates CD8(+) T Cell Specificity and Compensates for Loss of T Cell Receptor Contacts with the Specific Peptide
Triggering of a T cell requires interaction between its specific receptor (TCR) and a peptide antigen presented by a self–major histocompatibility complex (MHC) molecule. TCR recognition of self-MHC by itself falls below the threshold of detection in most systems due to low affinity. To study this i...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
1999
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193044/ https://ncbi.nlm.nih.gov/pubmed/10075972 |
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