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Recognition of the Major Histocompatibility Complex Restriction Element Modulates CD8(+) T Cell Specificity and Compensates for Loss of  T Cell Receptor Contacts with the Specific Peptide

Triggering of a T cell requires interaction between its specific receptor (TCR) and a peptide antigen presented by a self–major histocompatibility complex (MHC) molecule. TCR recognition of self-MHC by itself falls below the threshold of detection in most systems due to low affinity. To study this i...

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Autori principali: Sandberg, Johan K., Kärre, Klas, Glas, Rickard
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193044/
https://ncbi.nlm.nih.gov/pubmed/10075972
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