CD40 Activation Induces Apoptosis in Cultured Human Hepatocytes via Induction of Cell Surface Fas Ligand Expression and Amplifies Fas-mediated Hepatocyte Death during Allograft Rejection

We propose that a novel mechanism of hepatocyte apoptosis, involving a cooperative interaction between CD40 and Fas, is involved in the hepatocyte loss of chronic liver allograft rejection. We detected increased hepatocyte expression of Fas, Fas ligand (FasL), and CD40 associated with dropout of cen...

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Détails bibliographiques
Auteurs principaux: Afford, Simon C., Randhawa, Satinder, Eliopoulos, Aristides G., Hubscher, Stefan G., Young, Lawrence S., Adams, David H.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 1999
Sujets:
Brief Definitive Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192998/
https://ncbi.nlm.nih.gov/pubmed/9892626
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