Interleukin 12 Protects from a T Helper Type 1–mediated Autoimmune Disease, Experimental Autoimmune Uveitis, through a Mechanism Involving Interferon γ, Nitric Oxide, and Apoptosis

Pathogenic effector T cells in experimental autoimmune uveitis (EAU) are T helper type 1–like, and interleukin (IL)-12 is required for their generation and function. Therefore, we expected that IL-12 administration would have disease-enhancing effects. Mice were immunized with a uveitogenic regimen...

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Main Authors: Tarrant, Teresa K., Silver, Phyllis B., Wahlsten, Jennifer L., Rizzo, Luiz V., Chan, Chi-Chao, Wiggert, Barbara, Caspi, Rachel R.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1999
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192986/
https://ncbi.nlm.nih.gov/pubmed/9892605
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