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Suppression of angiogenesis and tumor growth by the inhibitor K1–5 generated by plasmin-mediated proteolysis

Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors. Previously, we reported that angiostatin, a potent angiogenesis inhibitor, is a proteolytic fragment containing the first four kringle modules of plasminogen. In this report, we demonstrate that urokina...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Cao, Renhai, Wu, Hua-Lin, Veitonmäki, Niina, Linden, Philip, Farnebo, Jacob, Shi, Guey-Yueh, Cao, Yihai
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21928/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10318952/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.10.5728
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