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Suppression of angiogenesis and tumor growth by the inhibitor K1–5 generated by plasmin-mediated proteolysis

Proteolytic enzymes are involved in generation of a number of endogenous angiogenesis inhibitors. Previously, we reported that angiostatin, a potent angiogenesis inhibitor, is a proteolytic fragment containing the first four kringle modules of plasminogen. In this report, we demonstrate that urokina...

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Detalhes bibliográficos
Main Authors: Cao, Renhai, Wu, Hua-Lin, Veitonmäki, Niina, Linden, Philip, Farnebo, Jacob, Shi, Guey-Yueh, Cao, Yihai
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21928/
https://ncbi.nlm.nih.gov/pubmed/10318952
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