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Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice
Mice deficient in the src related protein tyrosine kinase, Lyn, exhibit splenomegaly and accumulate lymphoblast-like and plasma cells in spleen as they age, resulting in elevated levels of serum IgM (10-20-fold of control) and glomerulonephritis due to the presence of immune complexes containing aut...
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| Formato: | Artigo |
|---|---|
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2192791/ https://ncbi.nlm.nih.gov/pubmed/9064343 |
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