Loading...

Intracellular Aggregation of Polypeptides with Expanded Polyglutamine Domain Is Stimulated by Stress-Activated Kinase Mekk1

Abnormal proteins, which escape chaperone-mediated refolding or proteasome-dependent degradation, aggregate and form inclusion bodies (IBs). In several neurodegenerative diseases, such IBs can be formed by proteins with expanded polyglutamine (polyQ) domains (e.g., huntingtin). This work studies the...

Full description

Saved in:
Bibliographic Details
Main Authors: Meriin, Anatoli B., Mabuchi, Katsuhide, Gabai, Vladimir L., Yaglom, Julia A., Kazantsev, Alex, Sherman, Michael Y.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192371/
https://ncbi.nlm.nih.gov/pubmed/11352944
Tags: Add Tag
No Tags, Be the first to tag this record!