Intracellular Aggregation of Polypeptides with Expanded Polyglutamine Domain Is Stimulated by Stress-Activated Kinase Mekk1

Abnormal proteins, which escape chaperone-mediated refolding or proteasome-dependent degradation, aggregate and form inclusion bodies (IBs). In several neurodegenerative diseases, such IBs can be formed by proteins with expanded polyglutamine (polyQ) domains (e.g., huntingtin). This work studies the...

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Bibliographic Details
Main Authors: Meriin, Anatoli B., Mabuchi, Katsuhide, Gabai, Vladimir L., Yaglom, Julia A., Kazantsev, Alex, Sherman, Michael Y.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192371/
https://ncbi.nlm.nih.gov/pubmed/11352944
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