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Interaction between CD8 and major histocompatibility complex (MHC) class I mediated by multiple contact surfaces that include the alpha 2 and alpha 3 domains of MHC class I

The cell surface glycoprotein CD8 functions as a coreceptor with the TCR on cytotoxic T lymphocytes. Mutational analysis of the binding site of CD8 for MHC class I predicted that distinct surfaces of CD8 would interact with both the alpha 2 and alpha 3 domains of class I. Using a cell-cell adhesion...

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Detalhes bibliográficos
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1995
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2192184/
https://ncbi.nlm.nih.gov/pubmed/7595198
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