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Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementarity determining region 2

We have investigated four secretion-deficient antibodies (Abs) derived from a panel of 46 mutant T15 anti-phosphocholine Abs, all of which have point mutations in the heavy chain (H) complementarity determining region 2 (CDR2). The level of secretion for these four Abs was < 10% of wild type when...

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Bibliografiske detaljer
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 1994
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2191617/
https://ncbi.nlm.nih.gov/pubmed/8046334
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