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Immunoglobulin gamma 2b transgenes inhibit heavy chain gene rearrangement, but cannot promote B cell development

Transgenic mice with a gamma 2b transgene were produced to investigate whether gamma 2b can replace mu in the development of B lymphocytes. Transgenic gamma 2b is present on the surface of B cells. Young transgenic mice have a dramatic decrease in B cell numbers, however, older mice have almost norm...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1993
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2191288/
https://ncbi.nlm.nih.gov/pubmed/8245779
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