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Acquisition of a Functional T Cell Receptor during T Lymphocyte Development Is Enforced by HEB and E2A Transcription Factors
The T cell receptor (TCR) is required for positive selection and the subsequent transition from the CD4(+)CD8(+) double-positive (DP) to the CD4(+) or CD8(+) single-positive (SP) stage of αβ T cell development. The molecular mechanism that maintains DP fate prior to the acquisition of a functional T...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2190753/ https://ncbi.nlm.nih.gov/pubmed/18093538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.10.014 |
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