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DNA damage, cellular senescence and organismal ageing: causal or correlative?

Cellular senescence has long been used as a cellular model for understanding mechanisms underlying the ageing process. Compelling evidence obtained in recent years demonstrate that DNA damage is a common mediator for both replicative senescence, which is triggered by telomere shortening, and prematu...

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Detalhes bibliográficos
Main Authors: Chen, Jian-Hua, Hales, C. Nicholes, Ozanne, Susan E.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190714/
https://ncbi.nlm.nih.gov/pubmed/17913751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm681
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