Analysis of the pharmacokinetic/pharmacodynamic relationship of a small molecule CXCR3 antagonist, NBI-74330, using a murine CXCR3 internalization assay

BACKGROUND AND PURPOSE: Pharmacokinetic/pharmacodynamic (PK/PD) models are necessary to relate the degree of drug exposure in vivo to target blockade and pharmacological efficacy. This manuscript describes a murine agonist-induced CXCR3 receptor internalization assay and demonstrates its utility for...

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Detalhes bibliográficos
Main Authors: Jopling, L A, Watt, G F, Fisher, S, Birch, H, Coggon, S, Christie, M I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2190000/
https://ncbi.nlm.nih.gov/pubmed/17982480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707519
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