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Internalization: what does it tell us about pharmacokinetic and pharmacodynamic properties of an antagonist?

Chemokine receptors play an important role in trafficking leukocytes within the body, a process that depends on expression of the receptors on the cell surface. Expression levels are regulated by the rate of internalizing receptor compared to the rate of recycling/recovering receptor. Internalizatio...

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Dettagli Bibliografici
Autore principale: Mueller, A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2007
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189999/
https://ncbi.nlm.nih.gov/pubmed/17982479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707521
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