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Internalization: what does it tell us about pharmacokinetic and pharmacodynamic properties of an antagonist?
Chemokine receptors play an important role in trafficking leukocytes within the body, a process that depends on expression of the receptors on the cell surface. Expression levels are regulated by the rate of internalizing receptor compared to the rate of recycling/recovering receptor. Internalizatio...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2189999/ https://ncbi.nlm.nih.gov/pubmed/17982479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707521 |
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