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Protein Ligands to Hur Modulate Its Interaction with Target Mrnas in Vivo

AU-rich elements (AREs) present in the 3′ untranslated regions of many protooncogene, cytokine, and lymphokine messages target them for rapid degradation. HuR, a ubiquitously expressed member of the ELAV (embryonic lethal abnormal vision) family of RNA binding proteins, selectively binds AREs and st...

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Hlavní autoři: Brennan, Christopher M., Gallouzi, Imed-Eddine, Steitz, Joan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2000
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2189805/
https://ncbi.nlm.nih.gov/pubmed/11018049
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