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Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response
The dynamics of somatic mutation in Ig variable genes was investigated in order to define a population of B cells undergoing mutation. BALB/cJ mice were injected with PC-KLH, and splenic RNA was prepared 5, 7, and 13 d later. The mRNA was annealed to gamma constant region primers to make cDNA transc...
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| Formato: | Artigo |
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| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1989
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2189359/ https://ncbi.nlm.nih.gov/pubmed/2499654 |
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