Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel–Lindau tumor suppressor function

The von Hippel–Lindau tumor suppressor protein pVHL assembles with cullin-2 (hCUL-2) and elongin B/C forming a protein complex, CBC(VHL), that resembles SKP1–CDC53–F-box protein ubiquitin ligases. Here, we show that hCUL-2 is modified by the conserved ubiquitin-like protein NEDD8 and that NEDD8–hCUL...

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Main Authors: Liakopoulos, Dimitris, Büsgen, Tanja, Brychzy, Alexander, Jentsch, Stefan, Pause, Arnim
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 1999
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC21890/
https://ncbi.nlm.nih.gov/pubmed/10318914
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