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Human monoclonal IgG isotypes differ in complement activating function at the level of C4 as well as C1q
Humanized antibodies are likely to have a major role in therapy and it is important to define their interaction with physiological effectors. By comparing a matched series of chimeric human mAbs we found that igG1 was most efficient in complement lysis, although IgG3 bound more C1q. To resolve this...
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| フォーマット: | Artigo |
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| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
1988
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2188986/ https://ncbi.nlm.nih.gov/pubmed/3260935 |
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