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Dissociation of membrane binding and lytic activities of the lymphocyte pore-forming protein (perforin)

Granules isolated from CTL and NK cells contain a cytolytic pore- forming protein (PFP/perforin). At low temperatures (on ice), PFP binds to erythrocyte membranes without producing hemolysis. Hemolysis occurs when the PFP-bound erythrocytes are warmed up to 37 degrees C, which defines a temperature-...

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Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1987
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2188309/
https://ncbi.nlm.nih.gov/pubmed/3494808
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