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Analysis of somatic mutations in kappa transgenes

We have examined the nature and localization of somatic mutations in three kappa transgenes cloned from IgG-secreting hybridomas. All of the mutations identified were single base substitutions. Mutations were localized to the variable (V) region and its flanking sequences. In every case, the nuclear...

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Bibliografske podrobnosti
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1990
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2188163/
https://ncbi.nlm.nih.gov/pubmed/2358776
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