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From HER2/Neu signal cascade to androgen receptor and its coactivators: A novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells

Overexpression of the HER2/Neu protooncogene has been linked to the progression of breast cancer. Here we demonstrate that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu. Using AG879, a HER2/Neu inhibitor, and PD98059, a MAP kinase inhibitor, a...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Yeh, Shuyuan, Lin, Hui-Kuan, Kang, Hong-Yo, Thin, Tin Htwe, Lin, Ming-Fong, Chang, Chawnshang
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1999
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21881/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10318905/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.10.5458
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