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Mechanism of regulation of Hsp70 chaperones by DnaJ cochaperones

Hsp70 chaperones assist a large variety of protein folding processes within the entire lifespan of proteins. Central to these activities is the regulation of Hsp70 by DnaJ cochaperones. DnaJ stimulates Hsp70 to hydrolyze ATP, a key step that closes its substrate-binding cavity and thus allows stable...

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Detalhes bibliográficos
Main Authors: Laufen, Thomas, Mayer, Matthias P., Beisel, Christian, Klostermeier, Dagmar, Mogk, Axel, Reinstein, Jochen, Bukau, Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1999
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21880/
https://ncbi.nlm.nih.gov/pubmed/10318904
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